cis-2-Aminocyclohexanol hydrochloride

cis-2-Aminocyclohexanol hydrochloride - Names and Identifiers

Name	Cis-2-Aminocyclohexanol Hydrochloride
Synonyms	AminocyclohexanolHCl,cis-2- Cis-2-Aminocyclohexanol Hydrochloride CIS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE Cyclohexanol, 2-aMino-, hydrochloride, cis- (1R,2S)-rel-2-AMinocyclohexanol hydrochloride cis-2-Aminocyclohexanol hydrochloride(racemic)
CAS	6936-47-6

cis-2-Aminocyclohexanol hydrochloride - Physico-chemical Properties

Molecular Formula	C6H14ClNO
Molar Mass	151.63
Melting Point	186-190 °C
Appearance	Crystalline Powder
Color	White to slightly beige
Storage Condition	Inert atmosphere,Room Temperature

cis-2-Aminocyclohexanol hydrochloride - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
HS Code	29221990

cis-2-Aminocyclohexanol hydrochloride - Reference Information

Preparation

Cis-2-aminocyclohexanol hydrochloride is prepared as follows:
1) Cyclohexene (5.00g;51.99mmol) is slowly added to a mixture of cooled m-chloroperbenzoic acid (9.87g;57.19mmol) in 125ml CH2Cl2. The reaction mixture was gradually warmed to room temperature overnight. The mixture was filtered, washed with concentrated NaHCO3 and concentrated in vacuum to obtain light yellow oily cycloheptene oxide, which is directly used in the next step.
2) In a sealed tube, cyclohexene oxide (5.44g;48.50mmol) and ammonium hydroxide solution (10ml) in 4ml of methanol are heated to 80°C for 72 hours. After removing the heat, the mixture was vacuum concentrated to obtain cis-2-aminocyclohexanol hydrochloride.

application

cis-2-aminocyclohexanol hydrochloride can be used as an intermediate in pharmaceutical synthesis.

Last Update：2024-04-09 21:01:54